The Bredesen ReCODE Protocol, developed by neurologist Dr. Dale Bredesen, is a personalized, multi-faceted approach aimed at preventing and reversing cognitive decline, particularly in Alzheimer’s disease. It’s grounded in functional medicine and targets the root causes of neurodegeneration rather than relying on a single pharmaceutical solution. Core Principles of the ReCODE Protocol include:
- Personalization: Begins with a “cognoscopy” at age 45—blood tests and cognitive assessments to tailor treatment.
- Holistic Strategy: Addresses multiple contributors to cognitive decline, including inflammation, insulin resistance, toxins, and pathogens.
Key Components
- Nutrition: Low-carb, plant-rich, high-fat diet (KetoFLEX 12/3); overnight fasting
- Exercise: Regular aerobic activity (30 mins, 5x/week)
- Sleep: Optimize sleep quality; rule out sleep apnea.
- Stress Mgmt.: Reduce chronic stress thru mindfulness and relaxation techniques.
- Brain Stimulation: Engage in cognitive training and learning.
- Detoxification: Remove toxins (e.g., heavy metals, mold); treat chronic infections.
- Supplementation: Personalized vitamins, minerals, and hormone support
Types of Alzheimer’s Addressed: Dr. Bredesen expanded the classification to six types: Inflammatory (“hot”), Atrophic (“cold”), Glycotoxic (“sweet”), Toxic (“vile”), Vascular (“pale”), Traumatic (“dazed”).
KetoFLEX 12/3 Diet Pyramid
- Base: Overnight fasting
- Next layers: Non-starchy vegetables, healthy fats, prebiotics, probiotics
- Top: Animal protein, fruit, occasional indulgences
While many anecdotal reports and case studies show promise, the protocol remains controversial due to limited large-scale clinical trials. Below is a sample daily plan based on the ReCODE Protocol principles. This plan follows the KetoFLEX 12/3 dietary approach and integrates lifestyle strategies aimed at optimizing brain health.
Morning (7:00–11:00 AM)
- Wake-Up Routine
- Hydrate with filtered water + pinch of Himalayan salt
- 10–15 minutes of mindfulness meditation or breathing exercises
- Light stretching or yoga
- Exercise
- 30 minutes of aerobic activity (e.g., brisk walk, cycling, swimming)
- Optional: resistance training 2–3x/week
- Breakfast (Optional)
- Skip if practicing intermittent fasting (12–16 hour fast)
- If eating: avocado smoothie with almond milk, spinach, MCT oil, and chia seeds
- Supplements to include Vit. D3, omega-3s, magnesium, B-complex, curcumin.
Midday (12:00–1:00 PM)
- Lunch
- Salad with mixed greens, olive oil, lemon juice, salmon or grilled tempeh
- Add nuts/seeds, fermented veggies (e.g., sauerkraut), and herbs
- Brain Engagement
- 20–30 minutes of cognitive training (apps like BrainHQ or Lumosity)
- Read or learn something new
Afternoon (2:00–5:00 PM)
- Work / Productive Time
- Focused tasks with short breaks
- Avoid multitasking to reduce cognitive load
- Snack (if needed)
- Handful of walnuts or coconut yogurt with cinnamon
- Stress Management
- Short walk outdoors or guided relaxation
- Journaling or gratitude practice
Evening (6:00–9:00 PM)
- Dinner
- Steamed cruciferous vegetables (broccoli, cauliflower) with GF beef or lentils
- Cauliflower rice sautéed in avocado oil
- Herbal tea (e.g., tulsi or chamomile)
- Digital Detox
- Limit screen time 1–2 hours before bed
- Use blue light filters if needed
- Sleep Prep
- Magnesium supplement or calming adaptogens (ashwagandha, L-theanine)
- Sleep in a cool, dark room; aim for 7–8 hours
Weekly Add-Ons
- Sauna or Epsom salt bath for detox
- Functional medicine check-ins
- Mold/toxin screening if applicable


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